We've taken a look back through Harry's royal life as he says goodbye to it.
There are many reasons that Harry is most people's favourite member of the royal family, and his relaxed and funny approach to engagements is always a hit with fans.
He was the first to get involved in games and activities, and always seemed to really care about the work he was doing and the people he was meeting.
His brother Prince William's wedding to Kate Middleton
Harry took up the role of best man when his brother tied the knot at Westminster Abbey, standing at his side as he said his vows.
He's always had a very special relationship with his sister-in-law Kate, so welcoming her officially into their unusual family was a huge moment.
After the guests tucked into a three-course meal at the evening reception at Buckingham Palace, Harry got to his feet to make his best man speech.
In her book Harry: Life, Loss, and Love, royal author Katie Nicholl writes: "It was affectionate, warm and funny and touched William deeply.
"The speech was peppered with Harry's classic sense of humour, and he ribbed his brother: 'William didn't have a romantic bone in his body before he met Kate, so I knew it was serious when William suddenly started cooing down the phone at Kate'.
"Famous for his mimicry, Harry then impersonated his brother calling Kate 'Babykins', to much laughter from the guests.
"When he said the couple's decade-long romance was his inspiration, there was a shy smile from Chelsy, while Kate shed a tear."
Becoming an uncle
Harry became an uncle for the first time when Kate and Wills welcomed Prince George in July 2013.
He said it was "fantastic to have another addition to the family", and that the newborn "was crying his eyes out" when he met him.
He told a reporter his mission as an uncle was to "make sure he has a good upbringing, and keep him out of harm's way and to make sure he has fun", before adding: the rest I'll leave to the parents".
Launching The Invictus Games
In 2013 Harry attended the Warrior Games in America and saw first hand how sport can help injured people physically, psychologically and socially.
He was so inspired by what he saw he started planning his own version, and in 2014 Invictus was born.
The international games sees wounded, injured or sick armed military personnel go head to head for their country in a number of sports including wheelchair basketball, sitting volleyball, and indoor rowing.
The games are Harry's great passion, and it was at one of the events that he officially stepped out with Meghan for the first time after announcing their relationship.
The website states: "The Invictus Games is about much more than just sport – it captures hearts, challenges minds and changes lives."
The fifth games were due to be held in The Hague, The Netherlands, in May this year but have been cancelled due to coronavirus Covid-19.
Marrying Meghan Markle
Harry got down on one knee and asked his American girlfriend Meghan Markle to be his wife at their two-bedroom Kensington Palace home Nottingham Cottage.
The couple were trying to cook a roast chicken at the time during what Meghan described as a "standard typical night in", saying it was "sweet, natural and very romantic".
They tied the knot six months later in a stunning service at St George's Chapel in Windsor Castle.
Hollywood met royalty as the couple said their vows, with the guestlist packed with Meghan's celebrity friends as well as the Queen, Duke and Duchess of Cambridge, Prince Charles and the rest of the Firm.
Harry couldn't have looked happier as he kissed his new bride on the chapel steps, with the evening celebrations continuing into the early hours.
Becoming a dad
Just a few months after their wedding, Meghan and Harry shared the happy news that they were expecting their first child.
On the eve of their royal tour of Australia and New Zealand, the Kensington Palace account tweeted: "Their Royal Highnesses The Duke and Duchess of Sussex are very pleased to announce that The Duchess of Sussex is expecting a baby in the Spring of 2019."
Archie Harrison Mountbatten-Windsor arrived at 5.26am on May 6.
Meghan gave birth to Archie at the private Portland Hospital in Westminster - which costs about £20,000.
As is traditional with royal babies, the birth was officially announced with a notice placed on an easel outside Buckingham Palace.
Hundreds of onlookers also watched from outside the gates as the framed message was put in place, describing the Queen and the Royal Family as being "delighted" at the baby's arrival.
Harry is proud father as he announces birth of first child
Speaking hours after the birth, proud dad Harry said his son is "absolutely to die for" and he was "over the moon".
The couple broke tradition and didn't pose on the hospital steps, instead introducing their son to the world at a photocall a few days later.
On the certificate, Meghan's job title is listed as 'Princess of the United Kingdom'.
However there have also been some bad moments for Harry, and on occasion he has had to issue public apologies.
Prince Diana's death
The most heartbreaking moment that sticks in most people's minds is when we saw a young Harry walking behind his mum Princess Diana's coffin at her funeral in 1997.
He stood shoulder to shoulder with Princes Philip, Charles and William and Diana's brother.
He was just 12 when she died in a car crash in Paris, and his hand written note rested on top of her coffin during the procession.
He has since said that no child "should be asked to do" what he was that day, but he's also said he's glad he was part of the day.
Nazi uniform fancy dress
In 2005 Prince Harry left people outraged when he dressed up as a Nazi for his friend's fancy dress birthday party.
He was heavily criticised by politicians, religious leaders and charities after the photos were leaked.
Pictures on the front page of the Sun under the headline Harry the Nazi showed the royal in a shirt with an eagle insignia on the front and a Swastika armband.
It was claimed it was the uniform of Rommel's Afrika Korps.
He was holding a drink and a cigarette in the shot.
The Prince was third in line to the throne at the time, and Clarence House quickly issued a statement saying he was sorry if he had caused any offence.
The scandal came just two weeks before the 60th anniversary of the liberation of Auschwitz.
The infamous Las Vegas trip
Harry said "I let myself down, I let my family down" after being pictured frolicking naked in Las Vegas in 2012.
The Royal spoke openly of his remorse over his wild partying, and revealed he struggles to balance his position as third-in-line to the throne while trying to have a "normal" army and social life.
Pictures showed Harry cupping his privates next to an unnamed naked woman and exposing his bottom during an August trip to Sin City, when he stayed at the £5,000-per-night Wynn Hotel.
British-born Carrie Reichert, then 32, revealed she spent 20 minutes alone with the prince in his hotel bedroom.
She was handpicked with nine other girls to join Harry in his penthouse suite but soon the royal heart-throb led her away so they could be together.
Carrie said: "We kissed, he was naked at the time, and pretty open. It was a drunken fumble. It wasn't romantic, just fun.
"He was a gentleman, but he was so wasted. The alcohol affected him. I was there for 15 to 20 minutes."
Addressing the trip a year later, he said: "At the end of the day I probably let myself down, I let my family down, I let other people down.
"But it was probably a classic example of me probably being too much army, and not enough prince. It's a simple case of that."
And just like that, they're done.
Meghan Markle and Prince Harry are no longer senior members of the Royal Family, and are no longer allowed to use their HRH Duke and Duchess of Sussex titles.
Everything will change for the couple, who have already moved to Canada and then onto LA,, including their working life, their security and even their names.
But the adjustment will be much bigger for Harry who has been royal his entire life, compared to Meghan who donned her first tiara less than two years ago.
Harry's years in the royal spotlight have been filled with ups and downs, with many proud moments and several he would probably rather forget.